Combination of Steven-Johnson syndrome and neuroleptic malignant syndrome following carbamazepine therapy: a rare occurrence.

Autor:	Sharma, Bhawna, Sannegowda, Raghavendra Bakki, Gandhi, Pankaj, Dubey, Parul, Panagariya, Ashok
Předmět:	NEUROLEPTIC malignant syndrome STEVENS-Johnson Syndrome CARBAMAZEPINE DIFFERENTIAL diagnosis DRUG side effects PATIENT aftercare HEALTH outcome assessment SYMPTOMS TREATMENT effectiveness DIAGNOSIS
Zdroj:	BMJ Case Reports; Jun2013, p1-4, 4p, 2 Color Photographs
Abstrakt:	Stevens-Johnson syndrome (SJS) is a severe, episodic, acute mucocutaneous reaction that is most often elicited by drugs and occasionally by infections. The drugs commonly implicated as the cause of SJS are anticonvulsants, sulfonamides, non-steroidal anti-inflammatory drugs and antibiotics. Carbamazepine (CBZ) has been commonly implicated in SJS. Neuroleptic malignant syndrome (NMS) is a rare, life-threatening but potentially treatable condition. Among the neuroleptics, haloperidol (parenteral) is implicated as a most common drug for NMS. Though rare, association of NMS with CBZ and association of NMS with toxic epidermal necrolysis (TEN) in a single patient after administration of neuroleptics has been reported in the literature before. However, a combination of NMS and SJS in a single patient after administration of CBZ has not been reported so far. We present a patient with seizure who developed SJS and NMS following administration of CBZ. [ABSTRACT FROM AUTHOR]
Databáze:	Complementary Index
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