| Autor: |
Fox, Lindsay L., Taylor, Terrie E., Pensulo, Paul, Liomba, Alice, Mpakiza, Ashley, Varela, Amanda, Glover, Simon J., Reeves, Mathew J., Seydel, Karl B. |
| Předmět: |
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| Zdroj: |
Journal of Infectious Diseases; Aug2013, Vol. 208 Issue 3, p500-503, 4p |
| Abstrakt: |
Some children with uncomplicated malaria progress to cerebral malaria despite appropriate treatment; identifying them in advance might improve their care. The objective of this study was to determine if plasma concentrations of a malaria protein, HRP2 (histidine-rich protein 2) would serve this purpose. Cases and controls were children presenting with uncomplicated malaria; the cases (n = 25) developed cerebral malaria, and the controls (n = 125) did not. Mean plasma HRP2 concentrations were significantly higher in the cases, and an HRP2 cutoff was identified that could predict disease progression (sensitivity and specificity, 88% for each). Quantitative measurements of HRP2 may be a useful screening tool. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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