| Autor: |
Perugini, M, Iarossi, D G, Kok, C H, Cummings, N, Diakiw, S M, Brown, A L, Danner, S, Bardy, P, Bik To, L, Wei, A H, Lewis, I D, D'Andrea, R J |
| Předmět: |
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| Zdroj: |
Leukemia (08876924); Jul2013, Vol. 27 Issue 7, p1588-1592, 5p, 1 Chart, 1 Graph |
| Abstrakt: |
The article presents a study which aims to assess DNA methylation in GADD45A in acute myeloid leukemia (AML) and co-occurrence with other mutations. The study used polymerase chain reaction (PCR) and Sequenom MassARRAY on bisulphite converted genomic DNA to determine GADD45A CpG1-4 methylation frequency. Results reveal that poor overall survival in AML was predicted in GADD45A methylation and G45Ame ability to predict poor outcome was independent of IDH1/2 and DNMT3A mutation. |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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