| Autor: |
Lie, A K W, Hui, C H, Rawling, T, Dyson, P G, Thorp, D, Benic, J, Rawling, C M, Toogood, I, Horvath, N, Simmons, P J, To, L B |
| Předmět: |
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| Zdroj: |
Bone Marrow Transplantation; 11/1/98, Vol. 22 Issue 9, p853, 5p |
| Abstrakt: |
For 10 consecutive patients in our unit who did not show a significant rise in blood progenitor cells within 14 days following chemotherapy and G-CSF, we increased the G-CSF dose from 5 to 10 μg/kg/day (n = 9) or from 10 to 15 μg/kg/day (n = 1). As a result, there were significant increases in total yield as well as yield per apheresis of mononuclear cells, CD34+ cells and CFU-GM (P < 0.025, <0.01 and <0.005, respectively). after g-csf dose escalation, six of the 10 patients had sufficient cd34+ cells for performing transplantation. These results demonstrate a dose-dependent response of progenitor cell mobilization by G-CSF when used in combination with chemotherapy. Moreover, increasing the dose of G-CSF as late as the third week of mobilization may still provide sufficient cell yield even with patients who did not show a significant mobilization with conventional doses of G-CSF. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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