| Autor: |
Cardoso, ML, Bezerra, JF, Oliveira, GHM, Soares, CD, Oliveira, SR, Souza, KSC, Silva, HPV, Silbiger, VN, Luchessi, AD, Fajardo, CM, Hirata, RDC, Almeida, MG, Hirata, MH, Rezende, AA |
| Předmět: |
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| Zdroj: |
Oral Diseases; Jul2013, Vol. 19 Issue 5, p507-512, 6p, 2 Diagrams, 3 Charts |
| Abstrakt: |
OBJECTIVE: The aim of this study was to investigate the contribution of 6 polymorphic variants of the MSXI gene in non-syndromic cleft lip and/or palate (NSCL/P). METHODS: Three hundred and fifty-eight individuals (158 NSCL/P cases and 200 controls) were genotyped by TaqMan allelic discrimination using predesigned SNP assays. Statistical analyses were conducted using the software SPSS 15.0 and the R statistical suite. Haplotype block structure and haplotype frequencies were determined using the Haploview. A P-value of 0.05 and confidence interval of 95% were used for all of statistical tests. RESULTS: The patients with non-syndromic cleft lip and/or palate were characterized by similar distribution of MSXI genotypes and allele in comparison to subjects without oral clefts (P > 0.05). Two haplotype blocks were constructed with polymorphisms of MSXI gene and haplotypes formed showed a similar frequency in patients with and without oral clefts. CONCLUSIONS: The present study provides no evidence that MSXI polymorphisms (rs3775261, rs1042484, rs12532, rs6446693, rs4464513 and rs1907998) play a major role in NSCL/P. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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