| Autor: |
Sheth, Raj D, Hobbs, Gerald R, Mullett, Martha |
| Předmět: |
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| Zdroj: |
Journal of Perinatology; Jan1999, Vol. 19 Issue 1, p40, 4p |
| Abstrakt: |
OBJECTIVE: To examine the influence of gestational age on seizures in the neonatal intensive care unit. STUDY DESIGN: A cohort of 4165 neonates admitted to a university intensive care unit between 1986 and 1995. The incidence, time of onset, and etiology of neonatal seizures in the cohort were distributed by gestational age. Logistic regression and t test were used to examine the relationship between gestational age and seizures in the neonatal intensive care unit. RESULTS: Seizures occurred in 356 (8.6%) infants. The seizure rate was parabolically related to gestational age, such that infants at 30 to 36 weeks' gestation had a 4.8% rate compared with 11.9% and 14.1% rates for infants <30 and >36 weeks, respectively (p < 0.001). Seizures manifested earlier in infants <30 weeks (2.3 ± 5.6 days of life) and >36 weeks (3.7 ± 8.7 days) gestational age compared with neonates 30 to 36 weeks (10.4 ± 14.5 days) (p < 0.001). Intraventricular hemorrhage was the principal etiology underlying the higher seizure rate for infants <30 weeks (p < 0.001). Hypoxicischemic encephalopathy and congenital malformations were primary factors for infants >36 weeks (p < 0.01). Nervous system infections were evenly distributed across gestational age. CONCLUSION: Gestational age exerts a considerable influence on the incidence, onset, and etiology of neonatal seizures. [ABSTRACT FROM AUTHOR] |
| Databáze: |
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