| Autor: |
van der Pouw Kraan, T C T M, van Veen, A, Boeije, L C M, van Tuyl, S A P, de Groot, E R, Stapel, S O, Bakker, A, Verweij, C L, Aarden, L A, van der Zee, J S |
| Předmět: |
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| Zdroj: |
Genes & Immunity; Sep99, Vol. 1 Issue 1, p61, 5p |
| Abstrakt: |
IL-13 plays a crucial role in the development of allergic asthma by several mechanisms, including induction of IgE antibodies, airway eosinophilia and hyper-reactivity. We previously established a deregulated production of IL-13 by T cells from allergic asthma patients. In this report we describe the identification of a novel IL-13 promoter polymorphism (C to T exchange) at position -1055. The IL-13 -1055 TT genotype is associated with allergic asthma (P = 0.002), altered regulation of IL-13 production (P < 0.002), and increased binding of nuclear proteins to this region. We postulate that the presence of this polymorphism predisposes to the development of allergic asthma. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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