| Autor: |
Yoshimoto, Tomohiro, Mizutani, Hitoshi, Tsutsui, Hiroko, Noben-Trauth, Nancy, Yamanaka, Kei-ichi, Tanaka, Minoru, Izumi, Shinzo, Okamura, Haruki, Paul, William E., Nakanishi, Kenji |
| Předmět: |
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| Zdroj: |
Nature Immunology; Aug2000, Vol. 1 Issue 2, p132, 6p |
| Abstrakt: |
Overproduction of immunoglobulin E (IgE) and T helper cell type 2 (TH2) cytokines, including interleukin 4 (IL-4), IL-5 and IL-13, can result in allergic disorders. Although it is known that IL-4 is critical to the polarization of naïve CD4+ T cells to a TH2 phenotype, both in vitro and in many in vivo systems, other factors that regulate in vivo IL-4 production and TH2 commitment are poorly understood. IL-18, an IL-1?like cytokine that requires cleavage with caspase-1 to become active, was found to increase IgE production in a CD4+ T cells-, IL-4? and STAT6?dependent fashion. IL-18 and T cell receptor?mediated stimulation could induce naïve CD4+ T cells to develop into IL-4?producing cells in vitro. Thus, caspase-1 and IL-18 may be critical in regulation of IgE production in vivo, providing a potential therapeutic target for allergic disorders. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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