| Autor: |
Ferris, Christopher D., Jaffrey, Samie R., Sawa, Akira, Takahashi, Masaaki, Brady, Stephen D., Barrow, Roxanne K., Tysoe, Steven A., Wolosker, Herman, Barañano, David E., Doré, Sylvain, Poss, Kenneth D., Snyder, Solomon H. |
| Předmět: |
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| Zdroj: |
Nature Cell Biology; jul99, Vol. 1 Issue 3, p152, 6p |
| Abstrakt: |
Haem oxygenase-1 (HO1) is a heat-shock protein that is induced by stressful stimuli. Here we demonstrate a cytoprotective role for HO1: cell death produced by serum deprivation, staurosporine or etoposide is markedly accentuated in cells from mice with a targeted deletion of the HO1 gene, and greatly reduced in cells that overexpress HO1. Iron efflux from cells is augmented by HO1 transfection and reduced in HO1-deficient fibroblasts. Iron accumulation in HO1-deficient cells explains their death: iron chelators protect HO1-deficient fibroblasts from cell death. Thus, cytoprotection by HO1 is attributable to its augmentation of iron efflux, reflecting a role for HO1 in modulating intracellular iron levels and regulating cell viability. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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