| Autor: |
DEVLIN, RICHARD G., FLEISS, PAUL M. |
| Zdroj: |
Journal of Clinical Pharmacology; Feb1981, Vol. 21 Issue 2/3, p110-113, 4p |
| Abstrakt: |
Blood and milk concentrations of captopril, a new antihypertensive agent, were studied in 12 lactating normotensive subjects after the administration of 100 mg captopril tablets on a three times daily regimen for a total of seven doses. Peak blood concentrations (± S.E.M.) of captopril after the administration of the seventh 100-mg tablet averaged 713.1 ± 140.6 ng/ml, as compared to average peak milk concentrations of 4.7 ± 0.7 ng/ml. Time to peak blood concentrations averaged 1.1 ± 0.2 hour, while time to peak milk concentrations averaged 3.8 ± 0.6 hours. The data suggest that the human breast selectively restricts the passage of captopril from blood into milk. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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