| Autor: |
Becker, Andreas, Hessenius, Carsten, Licha, Kai, Ebert, Bernd, Sukowski, Uwe, Semmler, Wolfhard, Wiedenmann, Bertram, Grötzinger, Carsten |
| Předmět: |
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| Zdroj: |
Nature Biotechnology; Apr2001, Vol. 19 Issue 4, p327, 5p |
| Abstrakt: |
We report here the in vivo diagnostic use of a peptide -- dye conjugate consisting of a cyanine dye and the somatostatin analog octreotate as a contrast agent for optical tumor imaging. When used in whole-body in vivo imaging of mouse xenografts, indotricarbocyanine-octreotate accumulated in tumor tissue. Tumor fluorescence rapidly increased and was more than threefold higher than that of normal tissue from 3 to 24 h after application. The targeting conjugate was also specifically internalized by primary human neuroendocrine tumor cells. This imaging approach, combining the specificity of ligand/receptor interaction with near-infrared fluorescence detection, may be applied in various other fields of cancer diagnosis. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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