| Autor: |
Usdin, T. B., Hoare, S. R. J., Wang, T., Mezey, É., Kowalak, J. A. |
| Předmět: |
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| Zdroj: |
Nature Neuroscience; nov99, Vol. 2 Issue 11, p941, 3p |
| Abstrakt: |
Activation by parathyroid hormone (PTH) and peripheral distribution the of PTH2 receptor (PTH2-R) are well described. Highest expression of PTH2-R is found in the brain, where PTH synthesis is undetectable. We have now purified and sequenced a new polypeptide from bovine hypothalamus (referred to here as tuberoinfundibular peptide of 39 residues; TIP39), a potent and selective agonist at the PTH2-R. The PTH2-R was highly expressed in hypothalamic areas that regulate pituitary hormone secretion and spinal cord regions involved in pain perception. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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