| Autor: |
Vural, Gülin, Ünlü, Mustafa, Atasever, Tamer, Özur, Izlem, Özdemir, Ayşegül, Gökçora, Nahide |
| Předmět: |
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| Zdroj: |
European Journal of Nuclear Medicine; 1997, Vol. 24 Issue 3, p312, 4p |
| Abstrakt: |
Indium-111 octreotide and thallium-201 scintigraphic studies were compared in 21 patients (16 with palpable and five with non-palpable lesions) suspected of having breast malignancies on the basis of mammography. Early (15 min) and late (3 h) [sup 201] Tl (111 MBq) and 4-h and 24-h [sup 111] In-octreotide (111–148 MBq) static planar anterior images (matrix 256×256) were obtained on separate days. Images were evaluated both visually and quantitatively. Biopsy was performed following the imaging studies. Histopathology revealed 17 breast carcinomas (15 cases of invasive ductal carcinoma, one mucinous adenocarcinoma and one intraductal carcinoma) and four benign breast lesions (two fibroadenomas, one abscess and one case of fat necrosis). The means histopathologcial tumour size (mean largest diameter) was 3.38±1.9 cm. [sup 111] In-octreotide detected 16 of the 17 breast cancers (94%) while [sup 201] Tl detected 13 of them (76%). Both [sup 111] In-octreotide and [sup 201] Tl missed one non-palpable carcinoma showing only an isolated cluster of microcalcifications on mammography. The smallest tumour size detected by both agents 1.5×1.5 cm. Of the four benign lesions, only the breast abscess revealed both [sup 201] Tl and [sup 111] In-octreotide uptake. [sup 111] In-octreotide scan also showed tracer uptake in five of the six patients with histologically proven axillary metastases, while four of these six patients showed [sup 201] Tl uptake. The tumour/background (T/B) ratios of late [sup 111] In-octreotide and [sup 201] Tl images were 1.71±0.38 and 1.46±0.30 respectively (P=0.039). In this preliminary study, [sup 111] In-octreotide yielded more favourable results than [sup 201] Tl in the detection of breast carcinomas. However, the diagnostic efficacy of [sup 111] In-octreotide imaging needs to be investigated in larger patient series. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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