| Autor: |
Lin, Shu-Ping, Chi, Tien-Yin, Lai, Tung-Yen, Liu, Mao-Chen |
| Zdroj: |
2012 IEEE-EMBS Conference on Biomedical Engineering & Sciences; 2012, p162-166, 5p |
| Abstrakt: |
A biocompatible and functional interface can improve medical applications of bioelectronic. Here, 3-aminopropyl trimethoxysilane (APTMS) and 3-mercaptopropyl trimethoxysilane (MPTMS) self-assembled monolayers (SAMs) were used to modify the surface of silicon nanowire (NW) -MOSFETs. AFM and electrical pH sensing verified which monolayer was capable of performing better electrical signal for subsequent immobilization of biomolecule. APTMS-SAM modified NW-MOSFETs showed more uniform modification on NW-MOSFETs and better electrical response to pH sensing. Biomolecule, such as antibody against prostate-specific antigen (anti-PSA), immobilized on APTMS-SAM modified NW-MOSFETs also successfully sensed those corresponding antigens in electrical measurement system. It elucidated that the suitable surface modification would profoundly affect the sensing response and sensitivity. [ABSTRACT FROM PUBLISHER] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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