| Autor: |
Lim, Sin-Liang, Tee, Sim-Hui |
| Zdroj: |
2012 IEEE-EMBS Conference on Biomedical Engineering & Sciences; 2012, p6-10, 5p |
| Abstrakt: |
Herpes simplex virus type 1 (HSV-1) has been reported to implicate in many human diseases. The virulence of HSV-1 and the invoked immunologic responses can be understood by studying the miRNA targets. As a regulatory gene, miRNAs were reported to involve in translational repression and mRNA cleavage. The binding of miRNA to mRNA has a consequence in the gene expression, and thus may influence the protein abundance. In this study, an in silico approach has been adopted to predict HSV-1 miRNA targets. Both seed region and miRNA 3′ base pairing have been taken into consideration for the complementarity analysis. Using our methods, 7 pairing sites have been identified for 6 HSV-1 miRNAs. Our work may shed light to the drug design and therapeutic strategies against HSV-1 infection. [ABSTRACT FROM PUBLISHER] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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