| Autor: |
Hel, Zdenek, Venzon, David, Poudyal, Monita, Tsai, Wen-Po, Giuliani, Laura, Woodward, Ruth, Chougnet, Claire, Shearer, Gene, Altman, John D., Watkins, David, Bischofberger, Norbert, Abimiku, Alashle, Markham, Phillip, Tartaglia, James, Franchini, Genoveffa |
| Předmět: |
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| Zdroj: |
Nature Medicine; Oct2000, Vol. 6 Issue 10, p1140, 7p |
| Abstrakt: |
Prolonged antiretroviral therapy (ART) is not likely to eradicate human immunodeficiency virus type I (HIV-I) infection. Here we explore the effect of therapeutic immunization in the context of ART during primary infection using the simian immunodeficiency virus (SIV[sub 251]) macaque model. Vaccination of rhesus macaques with the highly attenuated poxvirus-based NYVAC-SIV vaccine expressing structural genes elicited vigorous virus-specific CD4[sup +] and CD8[sup +] T cell responses in macaques that responded effectively to ART. Following discontinuation of a six-month ART regimen, viral rebound occurred in most animals, but was transient in six of eight vaccinated animals. Viral rebound was also transient in four of seven mock-vaccinated control animals. These data establish the importance of antiretroviral treatment during primary infection and demonstrate that virus-specific immune responses in the infected host can be expanded by therapeutic immunization. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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