| Autor: |
Fox, James G., Beck, Paul, Dangler, Charles A., Whary, Mark T., Wang, Timothy C., Shi, Hai Ning, Nagler-Anderson, Cathryn |
| Předmět: |
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| Zdroj: |
Nature Medicine; May2000, Vol. 6 Issue 5, p536, 7p |
| Abstrakt: |
Helicobacter pylori is causally associated with gastritis and gastric cancer. Some developing countries with a high prevalence of infection have high gastric cancer rates, whereas in others, these rates are Iow. The progression of helicobacter-induced gastritis and gastric atrophy mediated by type 1 T-helper cells may be modulated by concurrent parasitic infection. Here, in mice with concurrent helminth infection, helicobacter-associated gastric atrophy was reduced considerably despite chronic inflammation and high helicobacter colonization. This correlated with a substantial reduction in mRNA for cytokines and chemokines associated with a gastric inflammatory response of type 1 T-helper cells. Thus, concurrent enteric helminth infection can attenuate gastric atrophy, a premalignant lesion. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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