An improved and efficient synthesis for IPL576,092 and its analogues.

Autor: Liu, Jin, Huang, Rong, Zhu, Hongyou
Zdroj: Chemical Monthly / Monatshefte für Chemie; Jul2013, Vol. 144 Issue 7, p1081-1085, 5p
Abstrakt: An improved and efficient preparation of IPL576,092 was developed. The synthetic route involves selective allylic oxidation of ∆-sterols and subsequent hydroboration-oxidation as the key steps. In addition, two analogues were readily synthesized from commercially available steroidal compounds in two steps in the same way. Graphical abstract: [Figure not available: see fulltext.] [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index