Serum 25-hydroxyvitamin D levels and the risk of depression: A systematic review and meta-analysis.
| Autor: | Ju, Sang-Yhun, Lee, Y., Jeong, S. |
|---|---|
| Předmět: |
MENTAL depression risk factors
CHI-squared test CINAHL database CONFIDENCE intervals DOSE-response relationship in biochemistry EPIDEMIOLOGY INFORMATION storage & retrieval systems MEDICAL databases MEDICAL information storage & retrieval systems PSYCHOLOGY information storage & retrieval systems MEDLINE META-analysis ONLINE information services RESEARCH funding VITAMIN D SYSTEMATIC reviews DATA analysis DATA analysis software |
| Zdroj: | Journal of Nutrition, Health & Aging; May2013, Vol. 17 Issue 5, p447-455, 9p |
| Abstrakt: | Objective: No quantitative systematic review or meta-analysis of population-based epidemiological studies has been conducted to assess the association between serum 25-hydroxyvitamin D (25(OH)D) levels and the risk of depression. This study aimed to summarize the current evidence from cross-sectional and prospective cohort studies that have evaluated the association between 25(OH)D levels and the risk of depression. Methods: Relevant studies were identified by systematically searching the PubMed, EMBASE, Web of Science, and PsycINFO databases through April 2012. Cross-sectional and cohort studies that reported adjusted odds ratios (ORs) and 95% confidence intervals (CIs) for the association of interest were included. The reported risk estimates for 25(OH)D categories were recalculated, employing a comprehensive trend estimation from summarized dose-response data. A pooled OR was calculated separately for cross-sectional and cohort studies using random-effects models. Results: In the meta-analysis, 25(OH)D levels were significantly inversely associated with depression in 5 of 11 case-control studies and 2 of 5 cohort studies. The pooled estimate of the adjusted OR of depression in 11 cross-sectional studies (n = 43,137) was 0.96 (95% CI = 0.94-0.99, I = 63%) for a 10 ng/ml increase in 25(OH)D levels. The 5 included cohort studies comprised 12,648 participants, primarily elderly individuals, whose serum 25(OH)D levels were measured, and 2,663 experienced depression events during follow-up. The pooled adjusted OR of depression was 0.92 (95% CI = 0.87-0.98, I = 50%) for a 10 ng/ml increase in 25(OH)D levels. Conclusions: Our results indicate an inverse association between serum 25(OH)D levels and the risk of depression. Further studies are warranted to establish whether this association is causal. [ABSTRACT FROM AUTHOR] |
| Databáze: | Complementary Index |
| Externí odkaz: |
|
Full text from SpringerLink