| Autor: |
Purtell, Louise, Jenkins, Arthur, Viardot, Alexander, Herzog, Herbert, Sainsbury, Amanda, Smith, Arabella, Loughnan, Georgina, Steinbeck, Katharine, Campbell, Lesley V, Sze, Lisa |
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| Zdroj: |
Clinical Endocrinology; Jul2013, Vol. 79 Issue 1, p128-133, 6p, 2 Charts, 2 Graphs |
| Abstrakt: |
Context Individuals with Prader- Willi syndrome ( PWS) have a high cardiovascular risk, the mechanism of which is unclear. There may be dysfunction in the autonomic nervous system ( ANS) in PWS. Objective To measure, as indicators of cardiac autonomic function, postprandial heart rate variability ( HRV) and arterial stiffness in adults with PWS. Methods Ten adults with PWS were compared with 11 matched healthy obese subjects and 9 healthy lean subjects. Electrocardiographic traces and arterial stiffness were recorded over a period of 10 minutes at −60, 0, 30, 60, 120 and 240 minutes after consumption of a standardized 600- kCal breakfast. Frequency domain analysis was performed using fast Fourier transform to estimate power spectral density in the full spectrum and in low-frequency (LF 0·04-0·15 Hz) and high-frequency (HF 0·15-0·40 Hz) bands. Results ANCOVA revealed a reduced LF HRV meal response in adults with PWS compared with obese controls, with no differences in HF HRV, LF/ HF ratio, heart rate, total power or arterial stiffness meal responses. Conclusions This study assessed cardiac autonomic function in adults with PWS compared with matched obese and lean subjects in response to a meal. Results suggest impaired postprandial ANS responsiveness in PWS, which could contribute to both the known increased cardiovascular risk and obesity. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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