| Autor: |
Sobarzo, Natalia Quiñones, Venegas, Iván Montenegro, Sánchez, Cristian Salas, Catalán, Luis Espinoza, Rojas, Cristóbal Carrasco, Valdivia, Valentina Ulloa, García, Joan Villena, Fritis, Mauricio Cuellar |
| Předmět: |
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| Zdroj: |
Molecules; May2013, Vol. 18 Issue 5, p5517-5530, 14p, 2 Color Photographs, 4 Diagrams, 2 Charts, 2 Graphs |
| Abstrakt: |
The synthesis of a newangular analog 11 of cyclozonarone was achieved via Diels-Alder reaction between a sesquiterpene-1,3-diene and 1,4-benzoquinone. The cytotoxic activity of ent-cyclozonarone [(+)-10] and the angular (-)-cyclozonarone analog 11 has been determined in three human cancer cell lines and in normal fibroblasts using the sulforhodamine B assay. The analyzed isomers induce cell death in different cancer cell lines by eliciting nuclear condensation and fragmentation, decreasing mitochondrial membrane permeability and increasing caspase-3 activity, all traits indicating apoptosis, with the effects of (+)-10 being stronger than those of 11 in all cases. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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