| Abstrakt: |
The influence of intravenous peptide YY (PYY) on the gastric injury induced by 45% ethanol was investigated in urethane-anesthetized rats. PYY (25, 75, 125, and 250 pmol·kg[SUP-1]·[SUP-1]) significantly reduced gastric lesions by 36, 59, 40, and 38%, respectively. Antibody against ratPYY (2 mg/rat) injected intravenously completely prevented the gastroprotective effect of intravenous PYY (75 pmol·kg[SUP-1]·h[SUP-1]),whereas injected intracisternally (460 μg/20 μl), it significantly prevented intracisternal PYY (24 pmol/rat)-induced 58% reduction of ethanol lesions but not that induced by intravenous PYY. Vagotomy did not influence the gastroprotective effect of intravenous PYY. The Y[SUB1]/"PYY-preferring" receptor agonist [Pro[SUP34]]PYY (75 pmol·kg[SUP-1].h[SUP-1] iv) significantly decreased ethanol-induced gastric lesions by 82%, whereas [Leu[SUP31], Pro[SUP34]]NPY, a Y[SUB1]/Y[SUB3] agonist, and PYY-(3-36), a Y[SUB2] agonist, had no effect. These data indicate that PYY-infused intravenously at doses reported to mimic postprandial peak blood levels prevents ethanol-induced gastric injury through vagal independent pathways and PYY-preferring receptors. [ABSTRACT FROM AUTHOR] |
