Incorporation of 6-Thioguanine Nucleotides into DNA During Maintenance Therapy of Childhood Acute Lymphoblastic Leukemia-The Influence of Thiopurine Methyltransferase Genotypes.
| Autor: | Ebbesen, Maria S., Nersting, Jacob, Jacobsen, Jack H., Frandsen, Thomas L., Vettenranta, Kim, Abramsson, Jonas, Wesenberg, Finn, Schmiegelow, Kjeld |
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| Předmět: |
METHOTREXATE
NUCLEOTIDES DNA PRODRUGS GENES GENETIC polymorphisms HEALTH outcome assessment LYMPHOBLASTIC leukemia PHARMACEUTICAL arithmetic RESEARCH funding STATISTICS U-statistics DISEASE relapse DATA analysis TREATMENT effectiveness DATA analysis software DESCRIPTIVE statistics CHILDREN GENETICS THERAPEUTICS |
| Zdroj: | Journal of Clinical Pharmacology; Jun2013, Vol. 53 Issue 6, p670-674, 5p |
| Abstrakt: | The article reports on research conducted to investigate the effect of low activity thiopurine methyltransferase (TMPT) variants (TPMTLA) on the levels of the end‐point metabolite DNA‐TG and its relation to TPMT enzyme activity, Ery‐TGN, and erythrocyte levels of methylated metabolites (Ery‐ MeMP) in a cohort of children who were undergoing 6MP/MTX maintenance therapy for childhood acute lymphoblastic leukemia. Researchers found that TPMTLA patients had significantly lower TPMT activity. |
| Databáze: | Complementary Index |
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