| Autor: |
Kalder, Matthias, Ziller, Volker, Kyvernitakis, Ioannis, Knöll, Dana, Hars, Olaf, Hadji, Peyman |
| Předmět: |
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| Zdroj: |
Journal of Cancer Research & Clinical Oncology; Jun2013, Vol. 139 Issue 6, p915-923, 9p |
| Abstrakt: |
Purpose: Adjuvant treatment for hormone receptor-positive breast cancer in postmenopausal women with aromatase inhibitors is associated with increased bone loss depending on the compliance to treatment. Methods: In this bone substudy, bone mineral density (BMD) was assessed by dual energy X-ray absorptiometry at baseline and after 12- and 24-month treatment in 63 patients receiving Anastrozole as adjuvant treatment for hormone receptor-positive early breast cancer. To minimize the effects of confounders, a matched pair analysis (compliant N = 21, non-compliant N = 21) was performed. Results: Anastrozole treatment in compliant patients leads to a decrease in BMD (g/cm) at lumbar spine and total hip from baseline to 12 and 24 months (−2.57 % P = 0.004; −2.02 % P = 0.05; −2.57 % P = 0.001 and −4.18 % P = 0.003, respectively) compared to non-compliant patients (−1.71 % P = 0.050; −2.00 % P = 0.085; −1.65 % P = 0.055 and −3.20 % P = 0.005, respectively). Conclusions: Anastrozole treatment in compliant patients with breast cancer resulted in a larger, increase in bone loss at 12 and 24 months compared to non-compliant patients. Bone loss stabilized in both groups at the spine from 12- to 24-month treatment, whereas maintained at the total hip. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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