| Autor: |
Moscarella, E., Argenziano, G., Longo, C., Cota, C., Ardigò, M., Stigliano, V., Mete, L.S., Donati, P., Piana, S., Silipo, V., Catricalà, C., Albertini, G., Zalaudek, I. |
| Předmět: |
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| Zdroj: |
Journal of the European Academy of Dermatology & Venereology; Jun2013, Vol. 27 Issue 6, p699-705, 7p |
| Abstrakt: |
Background Muir-Torre syndrome (MTS) is an autosomal-dominant disorder characterized by the association of sebaceous tumors or keratoacanthomas with an early onset visceral cancer in the spectrum of Lynch syndrome. Observations A total of 20 sebaceous tumors including 18 sebaceous adenoma and two sebaceomas of six patients with MTS were analysed. Two main clinico-dermoscopic features were observed: (1) clinically pink to white papules/nodules with a central crater, dermoscopically characterized by radially arranged, elongated crown vessels surrounding opaque structureless yellow areas at times covered by blood crusts ( n = 13) and (2), clinically pink to yellow papules/nodules without a central crater, dermoscopically exhibiting a few, loosely arranged yellow comedo-like globules and branching arborizing vessels ( n = 7). Confocal microscopy was available in three sebaceous adenomas and revealed a good histopathologic correlation; sebaceous lobules were composed by clusters of ovoid cells with dark nuclei and bright, highly refractile glistening cytoplasm. They were delimited by a rim of epithelial cells, corresponding to basaloid cells. Conclusions A better characterization of clinical, dermoscopic and confocal microscopy features of sebaceous tumors may improve their recognition and consequently, aid to rise the suspect for MTS. [ABSTRACT FROM AUTHOR] |
| Databáze: |
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