Evaluation of Subchronic (13-Week) and Reproductive Toxicity Potential of Intravaginal Gel-Microemulsion Formulation of a Dual-function Phenyl Phosphate Derivative of Bromo-methoxy Zidovudine (Compound WHI-07) in B[sub 6]C[sub 3]F[sub 1] Mice.

Autor: D'Cruz, Osmond J., Waurzyniak, Barbara, Yiv, Seang H., Uckum, Fatih M.
Předmět:
Zdroj: Journal of Applied Toxicology; Jul/Aug2000, Vol. 20 Issue 4, p319, 7p, 5 Charts, 1 Graph
Abstrakt: Evaluates the toxicity potential of the intravaginal gel-microemulsion formulation of bromo-methoxy zidovudine derivative in mice. Failure of the derivative to affect the hematological and clinical chemistry profiles; Spermicidal potency; Absence of adverse effects on reproductive performance; Consideration of the derivative as non-toxic.
Databáze: Complementary Index
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