| Autor: |
Brimhall, Jae, Jhaveri, Malhar A., Yepes, Juan F. |
| Předmět: |
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| Zdroj: |
Special Care in Dentistry; May2013, Vol. 33 Issue 3, p123-127, 5p |
| Abstrakt: |
ABSTRACT Objectives To determine the efficacy and compare the side-effects of cevimeline and pilocarpine in the secretion of saliva in patients with xerostomia. Methods A randomized, cross-over, double blind study was designed. Fifteen patients with diagnosis of xerostomia were assigned to take either 5 mg of pilocarpine or 30 mg of cevimeline three times a day for four weeks. Salivary flow rates were measured during the initial baseline, first and second month appointments. Statistical analysis was carried out with ANOVA and post hoc t-tests. Results Twelve patients completed both medication treatments. Although both medications proved to increase salivary secretion, there was no significant difference between pilocarpine and cevimeline. Also, the perceived side-effects between the two medications were similar. Conclusion Both medications increased the secretion of saliva at the end of four weeks. However, there was a slightly higher increment in saliva with pilocarpine. However, the difference was not statistically significant. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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