| Autor: |
Sleebs, Brad E., Nguyen, Nghi H., Hughes, Andrew B. |
| Předmět: |
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| Zdroj: |
Synlett; 4/15/2013, Vol. 24 Issue 7, p823-826, 4p |
| Abstrakt: |
Stereoselective synthesis of N-Cbz-substituted ß-amino ketones exploiting the versatile 1,3-oxazin-6-one scaffold is reported. The 4-substituted 1,3-oxazinan-6-ones were enolized and acylated diastereoselectively by addition of various acyl halides. Acidic decarboxylation was then employed to smoothly transform the 5-acylated products to chiral ß-amino ketones. This methodology further highlights the utility of the 1,3-oxazinan-6-one as a scaffold to access valuable synthons that are used in the peptidomimetic field. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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