N-tert -Butoxycarbonylation of Structurally Diverse Amines and Sulfamides under Water-Mediated Catalyst-Free Conditions.

Autor: Cheraiet, Zinelaabine, Ouarna, Souad, Hessainia, Sihem, Berredjem, Malika, Aouf, Nour-Eddine
Předmět:
Zdroj: ISRN Organic Chemistry; 2012, p1-8, 8p
Abstrakt: A simple, efficient, and eco-friendly protocol for the N-Boc protection of the amine moiety in a variety of compounds with di-tert-butyl dicarbonate under water-acetone catalyst-free conditions is described. The corresponding monocarbamate is obtained in excellent yields on short reaction times. No competitive side reactions such as isocyanate urea and O-Boc were observed. This method represents a reasonable alternative to the previous reported protection procedures. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index