Diffuse Large B-Cell Lymphoma in Human T-Lymphotropic Virus Type 1 Carriers.

Autor: Beltran, Brady E., Quiñones, Pilar, Morales, Domingo, Revilla, Jose C., Alva, Jose C., Castillo, Jorge J.
Zdroj: Leukemia Research & Treatment; 2012, p1-4, 4p, 2 Charts
Abstrakt: We describe the clinical and pathological characteristics of seven patients who were human T-lymphotropic virus type 1 (HTLV-1) carriers and had a pathological diagnosis of de novo diffuse large B-cell lymphoma. Interestingly, three of our cases showed positive expression of Epstein-Barr-virus, (EBV-) encoded RNA within the tumor cells indicating a possible interaction between these two viruses. Furthermore, our three EBV-positive cases presented with similar clinical characteristics such as early clinical stage and low-risk indices. To the best of our knowledge, this is the first case series describing the characteristics of HTLV-1-positive DLBCL patients. The potential relationship between HTLV-1 and EBV should be further explored. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index