| Autor: |
Collemare, Jerome, van der Burgt, Ate, de Wit, Pierre J.G.M. |
| Předmět: |
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| Zdroj: |
Communicative & Integrative Biology; Mar/Apr2013, Vol. 6 Issue 2, pe23147-1-N.PAG, 5p |
| Abstrakt: |
The recent discovery of introner-like elements (ILEs) in six fungal species shed new light on the origin of regular spliceosomal introns (RSIs) and the mechanism of intron gains. These novel spliceosomal introns are found in hundreds of copies, are longer than RSIs and harbor stable predicted secondary structures. Yet, they are prone to degeneration in sequence and length to become undistinguishable from RSIs, suggesting that ILEs are predecessors of most RSIs. In most fungi, other near-identical introns were found duplicated in lower numbers in the same gene or in unrelated genes, indicating that intron duplication is a widespread phenomenon. However, ILEs are associated with the majority of intron gains, suggesting that the other types of duplication are of minor importance to the overall gains of introns. Our data support the hypothesis that ILEs' multiplication corresponds to the main mechanism of intron gain in fungi. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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