| Autor: |
Fowler Jr., Vance G., Allen, Keith B., Moreira Jr., Edson D., Moustafa, Moustafa, Isgro, Frank, Boucher, Helen W., Corey, G. Ralph, Carmeli, Yehuda, Betts, Robert, Hartzel, Jonathan S., Chan, Ivan S. F., McNeely, Tessie B., Kartsonis, Nicholas A., Guris, Dalya, Onorato, Matthew T., Smugar, Steven S., DiNubile, Mark J., Meulen, Ajoke Sobanio-ter |
| Předmět: |
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| Zdroj: |
JAMA: Journal of the American Medical Association; 4/3/2013, Vol. 309 Issue 13, p1368-1378, 11p |
| Abstrakt: |
The article discusses a study on the safety and efficacy of preoperative vaccination in the prevention of serious postoperative Staphylococcus aureus infection in patients undergoing cardiothoracic surgery. It describes the testing of a novel vaccine candidate (V710) containing a highly conserved S. aureus iron surface determinant B, which is shown to be immunogenic and well tolerated in the study's volunteers. Termination of the study was recommended by the independent data monitoring committee due to low efficacy and safety concerns. |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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