| Autor: |
Yun-yuan, Dong, Jun, Yang, Qi-jun, Liu, Zheng-hua, Wang |
| Zdroj: |
2012 3rd International Conference on System Science, Engineering Design & Manufacturing Informatization; 1/ 1/2012, p51-54, 4p |
| Abstrakt: |
One of the important problems in system biology is to discover the relationship between topological properties and functional features of proteins in protein-protein interaction (PPI) networks. There are many essential-nonhub proteins and lots of nonessential-nonhub proteins in the PPI network. Both essential-nonhub proteins and nonessential-nonhub proteins are low-connectivity proteins, but they have different lethality. In order to explain why nonessential-nonhub proteins are not essential, we compare them with essential-nonhub proteins from topological view. The comparison results show that there are statistical differences between nonessential-nonhub proteins and essential-nonhub proteins in centrality measures and clustering coefficient. [ABSTRACT FROM PUBLISHER] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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