| Autor: |
Baidyuk, E., Korshak, O., Karpov, A., Kudryavtsev, B., Sakuta, G. |
| Zdroj: |
Cell & Tissue Biology; Mar2013, Vol. 7 Issue 2, p140-148, 9p |
| Abstrakt: |
Morphological changes and regeneration activity of rat liver after experimental myocardial infarction (MI) caused by a permanent left coronary artery occlusion were investigated. It was shown that, 6 months after MI, considerable changes were observed in the rat liver circulatory system: the vessel amount per unit area increased by 118%, the thickness of their walls increased by 19%, and the average area of vessel lumens increased by 159%. The contribution of connective tissue 6 months after MI increased by more than one- and-a-half times in comparison with control. Inflammatory and necrotic changes in rat liver remained for 6 months after MI. The liver injury caused by MI leads to activation of regeneration processes in its parenchyma. Six months after MI, the number of 4 c-hepatocytes decreased by 12% in comparison with control and the number of 4 c×2- and 8 c-hepatocytes increased by 45 and 71%, respectively. Six months after MI, the hepatocyte ploidy increased by 11%. In this period, the dry mass of rat hepatocytes increased by 19%. Thus, liver regeneration after MI is stipulated by hepatocyte hypertrophy rather than their polyploidization. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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