A p53-p66Shc signalling pathway controls intracellular redox status, levels of oxidation-damaged DNA and oxidative stress-induced apoptosis.

Autor: Trinei, Mirella, Giorgio, Marco, Cicalese, Angelo, Barozzi, Sara, Ventura, Andrea, Migliaccio, Enrica, Milia, Elisabetta, Padura, Ines Martin, Raker, Veronica A., Maccarana, Marco, Petronilli, Valeria, Minucci, Saverio, Bernardi, Paolo, Lanfrancone, Luisa
Předmět:
Zdroj: Oncogene; 5/30/2002, Vol. 21 Issue 24, p3872, 7p, 3 Diagrams, 2 Graphs
Abstrakt: Presents a study that investigated the molecular mechanisms underlying oxidative stress resistance of the p66Shc. Significance of reactive oxygen species to the theory of aging; Background on p66Shc; Analysis of the role of the p53 tumor suppressor in the regulation of oxidative stress-induced apoptosis.
Databáze: Complementary Index