Heterozygosity for the tuberous sclerosis complex (TSC) gene products results in increased astrocyte numbers and decreased p27-Kip1 expression in TSC2+/- cells.

Autor: Uhlmann, Erik J., Apicelli, Anthony J., Baldwin, Rebecca L., Burke, Stephen P., Bajenaru, M. Livia, Onda, Hiroaki, Kwiatkowski, David, Gutmann, David H.
Předmět:
Zdroj: Oncogene; 6/6/2002, Vol. 21 Issue 25, p4050, 10p, 5 Diagrams, 10 Graphs
Abstrakt: Presents a study which hypothesized that dysregulated astrocyte function due to mutations in the tumor suppressor genes, TSC1 and TSC2, may contribute to the pathogenesis of such brain abnormalities. Background on tuberous sclerosis complex (TSC); Disorders in the brain that individuals with TSC develop; Benign tumors in TSC; Result of the linkage analysis of TSC.
Databáze: Complementary Index