Extracellular domain of TGBβ type III receptor inhibits angiogenesis and tumor growth in human cancer cells.

Autor: Bandyopadhyay, Abhik, Yong Zhu, Malik, Shazli N., Kreisberg, Jeffrey, Brattain, Michael G., Sprague, Eugene A., Jian Luo, Lopez-Casillas, Fernando, Sun, L.Z.
Předmět:
Zdroj: Oncogene; 5/16/2002, Vol. 21 Issue 22, p3541, 11p
Abstrakt: Presents a study which determined whether sequestration of endogenous transforming growth factors-beta (TGFβ) by the expression of a soluble TGFβ type III receptor, can reduce malignancy in human carcinoma cells and whether the tumor-suppressive activity of sRIII is associated with the inhibition of angiogenesis. Methodology; Results of the study; Conclusion.
Databáze: Complementary Index