| Autor: |
Hawkins, R.A., Tesdale, A.L., Prescott, R.J., Forster, T., McIntyre, M.A., Baker, P., Jack, W.J.L., Chetty, U., Dixon, J.M., Killen, M.E., Hulme, M.J., Miller, W.R. |
| Předmět: |
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| Zdroj: |
British Journal of Cancer; 7/1/2002, Vol. 87 Issue 1, p8-14, 7p |
| Abstrakt: |
In 1990, 215 patients with operable breast cancer were entered into a prospective study of the prognostic significance of five biochemical markers and 15 other factors (pathological/chronological/patient). After a median follow-up of 6.6 years, there were 77 recurrences and 77 deaths (59 breast cancer-related). By univariate analysis, patient outcome related significantly to 13 factors. By multivariate analysis, the most important of nine independent factors were: number of nodes involved, steroid receptors (for oestrogen or progestogen), age, clinical or pathological tumour size and grade. Receptors and grade exerted their influence only in the first 3 years. Progestogen receptors (immunohistochemical) and oestrogen receptors (biochemical) were of similar prognostic significance. The two receptors were correlated (r=+0.50, P=0.001) and displaced each other from the analytical model but some evidence for the additivity of their prognostic values was seen when their levels were discordant. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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