In silico Modeling and Global Optimization of Dynamic Bio-optical Processes for Probing, in vivo, Biological Features of Neoplasia.

Autor: Papoutsoglou, George, Stamatiadou, Maria, Balas, Costas
Zdroj: 2012 International Conference on Biomedical Engineering & Biotechnology; 1/ 1/2012, p332-335, 4p
Abstrakt: We present the first in silico simulation of biomarker uptake kinetics and of the associated dynamic optical signals, measured in vivo in neoplastic epithelial tissue. We introduce a new, non-invasive method for estimating and mapping of both structural and functional, neoplasia-correlated parameters. The method relies on model-based fitting of dynamic optical signals, measured in vivo, and on solving the inverse problem with the aid of global sensitivity analysis and global optimization approaches. [ABSTRACT FROM PUBLISHER]
Databáze: Complementary Index