P53 activation results in rapid dephosphorylation of the eIF4E-binding protein 4E-BP1, inhibition of ribosomal protein S6 kinase and inhibition of translation initiation.

Autor:	Horton, Lynn E., Bushell, Martin, Barth-Baus, Diane, Tilleray, Vivienne J., Clemens, Michael J., Hensold, Jack O.
Předmět:	MOUSE leukemia CELL lines P53 antioncogene CELL cycle PROTEIN synthesis
Zdroj:	Oncogene; 8/8/2002, Vol. 21 Issue 34, p5325, 10p, 4 Black and White Photographs, 1 Graph
Abstrakt:	Presents a study that investigated p53-dependent translational regulation using murine erythroleukemia cell line expressing a temperature-sensitive p53 mutant. Importance of p53 on cell cycle and apoptosis; Analysis of several potential mechanisms for regulating protein synthesis; Cause of a decrease in translation in cells with activated p53.
Databáze:	Complementary Index
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