| Autor: |
Seip, Ralf, Leyvi, Evgeniy, Raju, Balasundar I., Shi, William T., Bohmer, Marcel, Chlon, Ceciel, Sio, Charles, Reibling, Kristin, Swanson, Terri |
| Zdroj: |
2011 IEEE International Ultrasonics Symposium; 1/ 1/2011, p1894-1897, 4p |
| Abstrakt: |
The effect of tumor growth rate and treatment repeats are examined as parameters in pressure-mediated ultrasound treatments with microbubbles and Doxil in a murine breast cancer model. For this purpose, mice with a tumor doubling time of 8 and 13 days respectively received either a single or two ultrasound treatments (at 1 MHz/1 MPa) in conjunction with Definity microbubbles (1∶1 dilution) and Doxil (3 mg/Kg dose) after the tumor size reached 150 mm3. The tumor model was generated using MDA-MB-231-luc cells implanted into the lower mammary fat pad of SCID beige mice. At 15 days post-treatment, tumor size was reduced by 3±18%, 8±14%, and 20±10% as compared to control for the Doxil only, ultrasound + microbubbles + Doxil (single treatment), and ultrasound + microbubbles + Doxil (2 treatments) groups, respectively, in the mice with the slower growing tumors. The mice with the faster growing tumor yielded tumor size reductions of 46±27%, 71±10%, and 61±26%, respectively, for the same groups. We hypothesize that treatment efficacy is dependent on the dynamics of the tumor itself, even within the same cell line. [ABSTRACT FROM PUBLISHER] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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