Autor: |
Fridman, Osvaldo, Porcile, Rafael, Morales, Analía V., Gariglio, Luis O., Potenzoni, Miguel A., Turk Noceto, Paula C. |
Předmět: |
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Zdroj: |
Clinical & Experimental Hypertension; May2013, Vol. 35 Issue 3, p159-166, 8p |
Abstrakt: |
We examined the relationship between the 677C >T polymorphism in the MTHFR gene and tHcy in normotensive (NT) and hypertensive (HT) subjects and the influence of sex and age in a cross-sectional study. Smoking habits, history of vascular disease, diabetes, and tHcy were significantly associated with T allele as hypertension risk factors. The T allele was significantly related with higher tHcy in (i) men versus women ( P < .01), (ii) men and women older than 47 years versus the younger ones ( P < .05 and P < .001, respectively), (iii) HT women versus NT women ( P < .01), and (iv) older HT women versus older NT women ( P < .01). We found an association between the 677C>T MTHFR polymorphism and tHcy with hypertension that in women is manifested with age. [ABSTRACT FROM AUTHOR] |
Databáze: |
Complementary Index |
Externí odkaz: |
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