| Autor: |
Aragade, Prashant, Palkar, Mahesh, Ronad, Pradeepkumar, Satyanarayana, Darbhamulla |
| Zdroj: |
Medicinal Chemistry Research; May2013, Vol. 22 Issue 5, p2279-2283, 5p |
| Abstrakt: |
The purpose of this study was to evaluate the antimycobacterial activity of various pyrazole derivatives derived from the isoniazid pharmacophore along with coumarin scaffold. The synthesized title compounds ( 4a- 4k) were investigated for their in vitro antimycobacterial activity against Mycobacterium tuberculosis HRv using Resazurin MIC assay. The synthesized compounds exhibited MIC ranging from 0.625 to 2.50 μg/ml. Among the series tested, compound 3-[3-(4-fluorophenyl)-1-isonicotinoyl-1 H-pyrazol-5-yl]-2 H-chromen-2-one 4i was found to be the most active with MIC of 0.625 μg/ml. Graphical Abstract: Synthesis, spectral studies and antimycobacterial screening of a series of 11 new 2-pyrazole derivatives containing coumarin nucleus are described.[Figure not available: see fulltext.] [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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