Copper(II) complexes with derivatives of pyrazole as potential antioxidant enzyme mimics.

Autor: Kupcewicz, Bogumiła, Sobiesiak, Krzysztof, Malinowska, Katarzyna, Koprowska, Kamila, Czyz, Malgorzata, Keppler, Bernhard, Budzisz, Elżbieta
Zdroj: Medicinal Chemistry Research; May2013, Vol. 22 Issue 5, p2395-2402, 8p
Abstrakt: A series of six mononuclear Cu(II) complexes with pyrazole-based ligands: 5-(2-hydroxybenzoyl)-3-methyl-1-(2-pyridinyl)-1 H-pyrazol-4-phosphonic acid dimethyl ester ( 1a), 5-(2-hydroxyphenyl)-3-methyl-1-(2-pyridylo)-1 H-pyrazole-4-carboxylic acid methyl ester ( 1b) and 1-benzothiazol-2-yl-5-(2-hydroxyphenyl)-3-methyl-1 H-pyrazole-4-carboxylic acid methyl ester ( 1c) were characterized regarding to electrochemical and antioxidant properties. All complexes exhibit suitable Cu(II)/Cu(I) redox potential ( E) to act as antioxidant enzymes mimic. The five of these complexes were found to be trifunctional enzyme mimics possessing SOD, CAT and GPx-like catalytic activities. Moreover, Cu(II) complexes were capable to decrease ROS level in melanoma cells and observed effects were not merely a reflection of cytotoxicity. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index
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