The role of NO in the posterior hypothalamus in amygdala-generated pressor responses in conscious rats.

Autor: Özyurt Bayraktar, H., Yananlı, H., Terzioğlu, B., Oktay, Ş., Kaleli, M., Gören, M. Z.
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Zdroj: Autonomic & Autacoid Pharmacology; Apr2013, Vol. 33 Issue 1/2, p7-16, 10p
Abstrakt: The nitrergic system modulates cardiovascular functions of the central nucleus of amygdala ( Ce A) and the posterior hypothalamus ( PH) which are involved in the central regulation of the cardiovascular system. The aim of this study was to investigate the contribution of nitric oxide ( NO) in the PH in eliciting cardiovascular responses produced through electrical stimulation ( ES) of the Ce A. Rats were implanted with a stimulation electrode and a parenchymal cannula system into the Ce A and a parenchymal cannula or a microdialysis probe into the PH. The next day, the femoral artery was cannulated for haemodynamic measurement. The Ce A was electrically stimulated to produce cardiovascular response. The nitric oxide synthetase inhibitor, NG-nitro- L-arginine methyl ester ( L- NAME; 400 nmol/100 nl) or artificial cerebrospinal fluid were injected into the PH or the Ce A before the ES of the Ce A. The dialysates were collected from the PH to determine the L-citrulline and the L-glutamic acid levels., L- NAME injection into the Ce A but not to the PH suppressed the increases in the mean arterial pressure produced by the ES of the Ce A significantly; however, heart rate was not affected by L- NAME injection into either the PH or the Ce A. L-citrulline and L-glutamic acid levels in the PH were shown to be increased by the ES of the Ce A., NO is involved between the PH and the Ce A which has a considerable role in the central regulation of the cardiovascular system. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index
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