Habitual Exercise Correlates With Exercise Performance in Patients With Conotruncal Abnormalities.

Autor: O'Byrne, Michael, Mercer-Rosa, Laura, Ingall, Eitan, McBride, Michael, Paridon, Stephen, Goldmuntz, Elizabeth
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Zdroj: Pediatric Cardiology; Apr2013, Vol. 34 Issue 4, p853-860, 8p, 1 Chart, 4 Graphs
Abstrakt: Cardiopulmonary exercise testing (CPET), particularly maximal oxygen consumption (VOmax), has been used to assess the outcome for patients with palliated congenital heart disease (CHD). Small studies correlating VOmax with noninvasive imaging measures of ventricular function have led to the hypothesis that VOmax reflects cardiac performance. In other settings, physical training is associated with increased VOmax. The authors hypothesized that habitual exercise correlates with VOmax to a greater degree than ventricular function in a relatively healthy cohort of patients with palliated CHD. The habitual exercise behavior of 208 subjects with conotruncal abnormalities (tetralogy of Fallot, truncus arteriosus, and interrupted aortic arch) at the time of previously performed, study-based CPET and cardiac magnetic resonance imaging (CMR) were retrospectively assessed via questionnaire. The association of VOmax with habitual exercise duration and CMR measures of ventricular function was tested. Of 208 subjects, 89 (43 %) completed questionnaires, and 78 % of the 89 patients had a concurrent CMR. The mean VOmax was 76 ± 21 % of that predicted. The CMR-assessed left ventricular ejection fraction was 67.6 ± 7.4 %. The hours of habitual exercise per week correlated with VOmax ( p < 0.001; r = 0.14). No association was found between right and left ventricular ejection fraction, cardiac index, or right ventricular end-diastolic volume and VOmax. In this study, VOmax correlated with habitual exercise to a greater degree than CMR measurements of ventricular function. These findings highlight the importance of considering the contribution of noncardiac factors when exercise data in both clinical and research settings are interpreted. The contribution of these factors to clinical outcomes deserves further study. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index
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