Absence of somatic SDHD mutations in sporadic neuroendocrine tumors and detection of two germline variants in paraganglioma patients.

Autor: Perren, Aurel, Barghorn, Andre, Schmid, Sonja, Saremaslani, Parvin, Roth, Jurgen, Heitz, Phillip U., Komminoth, Paul
Předmět:
Zdroj: Oncogene; 10/24/2002, Vol. 21 Issue 49, p7605, 4p, 2 Charts, 2 Graphs
Abstrakt: Determines whether tumor suppresor gene SDHD plays a role in the development of sporadic neuroendocrine tumors (NET). Description of the tumors of the diffuse neuroendocrine system; Inheritance pattern of the disease phenotype of familial PGL1 caused by SDHD mutations; Lack of somatic SDHD mutations in NET of the lung, gastrointestinal trace, pancreas and parathyroids.
Databáze: Complementary Index