| Autor: |
Mackeen, Mukram M., Mooi, Lim Y., Amran, Mohidin, Mat, Nashriyah, Lajis, Nordin H., Ali, Abdul M. |
| Zdroj: |
Evidence-based Complementary & Alternative Medicine (eCAM); 2012, Vol. 2012, p1-5, 5p |
| Abstrakt: |
The in vitro antitumour-promoting, cytotoxic, and antioxidant activities of two ester derivatives of garcinia acid, that is, 2- (butoxycarbonylmethyl)-3-butoxycarbonyl-2-hydroxy-3-propanolide (1) and 1',1''-dibutyl methyl hydroxycitrate (2), that had been previously isolated from the fruits of Garcinia atroviridis Griff. ex T. Anders (Guttiferae), were examined. Based on the inhibition of Epstein-Barr virus early antigen (EBV-EA) activation, compound 1 (IC50: 70μ M) showed much higher (8-fold) antitumour-promoting activity than compound 2 (IC50: 560 μ M). In addition, both compounds were nontoxic towards CE MSS (human T-lymphoblastic leukemia) cells (CD50: >100 μ M), Raji (human B-lymphoblastoid) cells (CD50: >600 μ M), and brine shrimp (LD50: >300 μ M). Although the antitumour-promoting activity of compound 1 is moderate compared with the known antitumour promoter genistein, its non-toxicity suggests the potential of compound 1 and related structures as chemopreventive agents. The weak antioxidant activity displayed by both compounds also suggested that the primary antitumour-promoting mechanism of compound 1 did not involve oxidative-stress quenching. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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