| Autor: |
Modupe, Oyatogun Grace, Ayodeji, Esan Temitope, Obhioneh, Oziegbe Elizabeth, Adebiyi, Kehinde E., Adetoro, Togun Rachel, Dare, Enoch O., Oyebamiji, Adeoye Mosobalaje |
| Předmět: |
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| Zdroj: |
Journal of Osteology & Biomaterials; 2012, Vol. 3 Issue 1, p21-27, 7p |
| Abstrakt: |
Aim: This work attempted to process and investigates the suitability of cowry shell as a bone graft substitute material. Materials and Methods: The cowry shell was washed with distilled water to remove foreign bodies such as dust, dirt, and insect larva which might have entered it from the sea. They were crushed and dried in the oven at 80°C for about 20 minutes. The shell was pulverized into powdery form and sieved to obtain a particle size of 300 µm. Biochemical analysis was carried out to ascertain the types and quantity of proteins present in the cowry shell. The powder was compacted into the different test piece specimen for the different mechanical tests and sintered at 490C. This was followed by mechanical and chemical characterization of the material. Finally, in-vivo test was carried out to ascertain the materials' biocompatibility with bone cells. Results: The immunoassay results show that the use of cowry shell as bone graft substitute will not present any antigenic interaction that may results in adverse immunological response in the host. The mechanical test also shows that the hardness and compressive strength of the processed cowry shell is comparable to that of other bone graft substitute materials. The material was however very brittle, subsequently limiting its application for load bearing. The in-vivo results, showed integration of the materials with the bone cells at 14th day post insertion. Conclusion: The material was found to be biocompatible with bone cells: Thus affirming the materials suitability as bone graft substitute for bone repair and replacement. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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