Nucleophilic 5-endo-trig Cyclization of 3,3-Difluoroallylic Ketone Enolates:Synthesis of 5-Fluorinated 2-Alkylidene-2,3-dihydrofurans.

Autor:	Fujita, Takeshi, Sakoda, Kotaro, Ikeda, Masahiro, Hattori, Masahiro, Ichikawa, Junji
Předmět:	NUCLEOPHILIC addition (Chemistry) ORGANIC compounds OXO compounds KETOACIDOSIS LIGHT elements
Zdroj:	Synlett; Jan2013, Vol. 24 Issue 1, p57-60, 4p
Abstrakt:	3,3-Difluoroallylic ketones readily undergo nucleophilic 5-endo-trig cyclization through their metal enolates to afford 5-fluorinated 2-alkylidene-2,3-dihydrofurans. O-Cyclization exclusively occurred via intramolecular substitution of the vinylic fluorines. [ABSTRACT FROM AUTHOR]
Databáze:	Complementary Index
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